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Experimentation being Conducted at WaRPRC

It is impossible to keep totally up-to-date on the various experiments being conducted at the Washington Regional Primate Research Center (or any of the other NIH-funded giant primate vivisection facilities around the country). The reason for this is the ungodly amount of money Congress continues to give to these facilities. And, like nearly all recipients of federal tax revenues, they have to keep spending the money to show that they "really" have a need for it. So, more experiments are conceived and begun all the time. Others are abandoned. It's all about money, money, money ...


MICHAEL B. AGY <magy@u.washington.edu>, SHIU-LOK HU <hus@u.washington.edu> and LAWRENCE COREY <lcorey@u.washington.edu> are continuing a ten-years-long series of experiments, infecting pig-tailed and crab-eating macaques intravenously, intrarectally and intravaginally with SIV and HIV-1.

CHARLES E. ALPERS <calp@u.washington.edu> In 1998 Alpers was infecting pig-tailed macaques and crab-eating macaques with SIV, HIV-2, and HIV-l because he wanted to study the effects of these diseases on the monkeys’ kidneys. Now he says, "Preliminary studies have shown that a proportion of macaques, when experimentally infected with HIV2, will develop thrombotic microangiopathy ... We will define the chronology of this disease process in infected macaques by means of clinical monitoring of serum and urine for evidence of organ dysfunction, immunological abnormalities including those involving lymphocyte subsets, and serologic evidence of infection. Morphologic correlation will be established by periodic biopsy and by necropsy studies of relevant affected organs including heart, lung, brain, and gut." (Meet Chuck!)

DAVID M. ANDERSON <danderso@u.washington.edu> worked to discover the dose of HIV required to infect female pig-tailed macaques vaginally and rectally.

GAIL D. ANDERSON was culturing macaque adrenal glands, testes and ovaries obtained from the RPRC Tissue Program to investigate the effect of antiepileptic drugs on gland produced enzymes. (1998)

MARJORIE E. ANDERSON <andermar@u.washington.edu> discovered, in her attempt to understand brain chemical interactions, that tubing, surgically embedded in a monkey's brain (species undisclosed), may cause localized paralysis. Now she is experimenting on monkeys treated chronically with MPTP, a drug that causes tremors, ridgidity, lack of balance, and many Parkinson's disease-like symptoms in monkeys. (Meet Marjorie!)

ROBERT G. ANDREWS is looking for a way to transfer genes between individuals. He is attempting this by transplanting bone marrow between monkeys of some undisclosed species.

GREGORY A. BOSCH was trying to determine which minute part of a staphylococcus bacteria would cause a monkey to vomit and have diarrhea. (1998)

MARNIX L. BOSCH <marnix@u.washington.edu> discovered a new class of herpes viruses associated with AIDS related Kaposi 's sarcoma, a type of cancer. Bosch infected four crab-eating macaques and six rhesus macaques with the new virus. The rhesus became ill; the crab-eating macaques did not. In a separate study Bosch infected new-born rhesus orally, intravenously, and rectally with HIV-1.

DOUGLAS M. BOWDEN <dmbowden@u.washington.edu> In 1998 Bowden surgically installed cranial implants in two monkeys and tested whether macaques (species undisclosed) learned more rapidly with a reward of direct electrical stimulation to the medial dorsal nucleus of the thalamus. Today, Bowden is active in the creation of the Template Atlas of the Primate Brain. (Meet Doug!)

JERRY BOOGAARD tested an inner ear implant in monkeys and Guinea pigs. He said this new device might offered some deaf humans greater speech discrimination. But such implants were already in use in humans.

WILLIAM J. BREMNER was studying male contraception by recording the effects of various drugs on the growth of the prostate gland in castrated monkeys. He seems have given up on monkeys and has moved on to humans.

STEVEN L. BUCK used an "in vitro" preparation of the macaque retina (species undisclosed) in an attempt to understand color vision in humans.

JOHN A. BUFORD was studying brain/spinal chord interactions associated with reaching with the hand.

THOMAS M. BURBACHER <tmb@u.washington.edu> "My research program is focused on identifying alterations in brain development and function due to prenatal exposure to neuroactive substances. The program is one of only a handful in the country using nonhuman primates." One must ask what "a handful" might mean here? There have been at least 117 studies published since1976 on ethanol or mercury exposure (which is the area of Burbacher's interest) in animals (mostly monkeys). From 1995 there have been nearly 2000 published studies on ethanol exposure in utero in humans and over 400 studies on mercury exposure in humans in utero. And 123 on methanol in utero exposure. Perhaps Burbacher means that only a handful of such studies have paid his salary. (Meet Tom!, Well, actually you can't any more. Tom took his personal page down some time ago. He is still quite busy however. He directs the Infant Primate Laboratory and publishes quite frequently about the many ways one can poison monkeys.)

CLARK, EDWARD A. <eclark@bart.rprc.washington.edu> is attempting to determine whether HIV affects nerve cells in macaques.

CLOWES, ALEXANDER W. <clowes@u.washington.edu> is injuring baboons’ arteries to study arterial grafts. "As an approach to gene therapy, we are seeding modified smooth muscle cells into [experimentally] injured arteries and vascular grafts in several different species (rat, dog, baboon). (Meet Al!)

COREY, LAWRENCE <lcorey@u.washington.edu>is growing human viruses on monkey kidney tissue. [Evidence suggests that this same technique is what introduced cancer causing simian virus 40 (SV-40) and perhaps some unidentified precursor to HIV into the human population.]

DACEY, DENNIS M. <dmd@u.washington.edu> writes, "Detailed knowledge of human retinal cell types is ... extremely limited, lagging far behind a rapidly growing understanding of macaque retinal neurons." So, he explains, "Our experiments are directed at determining which combinations of cell types are responsible for coding information about blue/yellow and red/green channels. We use intracellular recording and imaging in a unique preparation of living retina ..." apparently using rhesus, stump-tailed, and crab-eating macaque retinas. "Our longterm research goal is to characterize the functional organization of the macaque retina as a model for understanding the early stages of the human visual processing." (Meet Dennis!)

DILLER, LISA C. is involved in workwith Dacey (above).

DUBACH, MARK <mdubach@u.washington.edu> was hoping to discover an area in a monkey’s brain similar to an area in a rat’s brain which will cause convulsions when a particular chemical is injected into it. Now he is working with Guderson (below). He writes, "In "Limbic Seizures and Neurobehavioral Development" (V. Gunderson) my principal role is to arrange for the induction of seizures by focal drug injections at sensitive sites in the brain. In 1998 we used my curved-injector technique to treat an extended portion of the entorhinal cortex. The first acute injection of bicuculline in each of five monkeys led to seizure activity in the hippocampus within 10-20 min, as well as acute behavioral signs of complex partial seizures..."

"In "Dopaminergic and GABAergic Actions of Pallidal Discharge" (M. Anderson) my role has been to implant an access fiber for repeated drug application throughout several millimeters of the putamen [a brain region]. A paper describing the method was published in 1998. In "Neural Substrate of Learning" (D.Bowden), which involves electrical stimulation of the brain as a reward for learning a visuomotor task, I am responsible for platform implantations to enable the targeting of subcortical regions for electrical stimulation. Long-range plans include the implantation of an access fiber in prefrontal cortex to examine the effects of drug administration on learning." (Meet this piece of scum.)

EATON, DAVID L. <deaton@u.washington.edu> was using non-human primates, probably pig-tailed macaques, to test whether two different drugs might protect them from the carcinogenic effects of the fungi Aspergillus flavus and Aspergillus parasiticus, both common molds in humid tropical climates. He now seems to have moved on to propagandizing middle school and high school teachers. (Meet Dave!)

FETZ, EBERHARD E. <fetz@u.washington.edu> is implanting electrodes in the brains and spinal chords of monkeys (species undisclosed) and then forcing them to perform various tasks while he records the electrical variations from the implants. (Meet Eberhard!)

FLICKINGER, CHARLES J. <cjf@virginia.edu> was using macaque ovaries from WaRPRC to look for a new contraceptive.(1998). He works at the University of Virginia. (Meet Charles!)

FUCHS, ALBERT F. <fuchs@u.washington.edu> is placing monkeys (species undisclosed) in some sort of restraint device and recording the coordination of head
and eye movement while the monkey’s head is free to move and after a brake has been applied. He has also recorded this coordination after forcing the monkey to wear magnifying lenses over its eyes. (Meet Al!)

On March 18, 2000, Al got pulled over for driving erradically in the Pleasant Hills suburb of Pittsburgh. The police officer smelled alchohol and administered sobiety tests. Al failed and was arrested. He was then asked to submit to a blood test, which he refused. He told the officer that he had a fear of needles. Al's driver's liscence was suspended for a year. Al appealed, but lost his case. [From court records: Commonwealth Court of Pennsylvania No. 246 C.D. 2001.]

We wonder where Al got his fear of needles? And what the psychological motivation for experimenting on monkeys strapped into chairs might be for someone with such a fear?

GAUR, LAKSHMI <lgaur@u.washington.edu> is attempting to create diabetes-like symptoms in monkeys.

GLEICH, GERALD J. commented, "Although we purify eosinophils [a type of white blood cell] from human blood on an almost daily basis, the purification of monkey eosinophils was exceedingly difficult and we were not able to achieve the degree of homogeneity that we regularly achieve with human eosinophils." (1998)

GLENNY, ROBB W. <glenny@u.washington.edu> reported, "Three baboons (25.5-27.0 kg) were anesthetized ... Different colors of fluorescent microspheres ... were injected ... while the animals were in the supine, prone, head-up (repeated), and head-down (repeated) postures. After the last microsphere injection, the animals were killed and their lungs were excised, dried ... and diced ... We conclude that gravity plays a minor role in determining pulmonary perfusion heterogeneity in upright primates." (Meet Robb!)

GLOMSET, JOHN A. is studying neurochemicals in an undisclosed species of monkey. (Meet John!)

GOODMAN, MORRIS <mg@tree.roc.wayne.edu> has suggested the old world monkeys and new world monkeys are more distant from an evotutionary perspective than has been thought. As interesting as such conjectures are, his method of inquiry is the analysis of certain genes in developing monkey embryos and fetuses whhic he recieves from WaRPRC. He is on staff at Wayne State. (Meet Morris!)

GREENBERG, PHILIP D. writes, "The studies will be performed in a non-human primate model with SHIV, a chimeric virus comprised of elements of HIV-1
and SIV, as the challenge virus." (Meet Phil!)

GUNDERSON, VIRGINIA M. <gunder@u.washington.edu> is learning how to bolt the heads of three month-old baby monkeys into a restraint device and inject chemicals into their brains to induce seizures. Other than getting to learn a new technique, she is asking whether seizures might interfere with later neurobehavioral development in an undisclosed species of monkey. Her university bio page makes the outlandish claim that her methods are the same as those "used to study human development."

"The primary goal of this research is to develop a macaque monkey model for complex-partial seizures during the first year of life....There is concern that early seizures may adversely affect cognitive and emotional functioning during childhood [in humans]. Cranial assemblies are implanted on project animals using stereotaxic surgical techniques. In previous years we attempted to induce seizures by the microinfusion of bicuculline methiodide into an area deep within the piriform cortex.

Unfortunately this procedure was not reliable in obtaining seizures on a regular basis."

Imagine being disappointed because the drug you elect to inject directly into an infant monkey's brain cause seizures only a part of the time.

"Therefore, we tried two other protocols. First, in four animals we attempted to induce seizures by the infusion of drug into the hippocampus. Again, the results were inconsistent. Second, in another four animals, we induced seizures by infusing drug into the entorhinal cortex. The latter procedure was very successful, and we were able to obtain seizures in every animal on our first attempt." A real life-saving breakthrough. (Meet Virginia! Well, you can't actually. Virginia receieved some negative publicity after this information was published on the Internet and now keeps a very low profile. In fact, she now goes by the name of Virginia Batterson for the classes she teaches at the University of Washington. Maybe she doesn't want her students searching for 'V Gunderson' and finding out that their professor is a monster.)

Currently, and what should be ironically, but isn't in the world of primate vivisection, Virginia is a part of the university's Animal Care and Use Committee (IACUC). This means that she gets to decide whether what other researchers are doing, or want to do, to animals should or should not be allowed. What in the world wouldn't Virginia allow to be done to an animal? What a mockery. You can give her a call at: (206) 543-8547.

HA, JAMES C. <jcha @ u.washington.edu> In 1998, Ha, with other members of WaRPRC, published "Fetal, infant, and maternal toxicity of zidovudine (azidothymidine) administered throughout pregnancy in Macaca nemestrina." in the May edition of the Journal of Acquired Immune Deficency Syndrome and HumanRetrovirology. The abstract for this study is worthy of scrutiny:

"The toxicity of azidothymidine (AZT) was studied in monkey dams and fetuses that were exposed to the drug over the entire gestational period. Fourteen virus-free female macaques (Macaca nemestrina) were randomly assigned to AZT or control groups. AZT animals received the drug through a gastric catheter at a dose of 1.5 mg/kg every 4 hours, which produced plasma concentrations similar to those in humans taking 500 to 600 mg/day of AZT. Control animals received water placebo, also through gastric catheter [a tube implanted into their stomachs]. Some animals participated in both groups. All females were mated with the same male; 41 matings produced 20 pregnancies, of which 16 were carried to term (9 in AZT females; 7 in control females). The AZT animals developed an asymptomatic macrocytic anemia, but hematologic parameters returned to normal when AZT was discontinued. Total leukocyte count decreased during pregnancy and was further affected by AZT administration. AZT-exposed infants were mildly anemic at birth. AZT caused deficits in growth, rooting and snouting reflexes, and the ability to fixate and follow near stimuli visually, but the deficits disappeared over time. These data indicate that early exposure to AZT in utero should have no irreversible adverse effects on the fetus."

Compare this with the "Lack of Long-term Effects ..." and see whether Ha's work was cited. If it wasn't, it means that Ha's work was ignored by human clinical researchers. (Meet James!)

HAGOPIAN, WILLIAM A.<wah@u.washington.edu>is using pig tailed macaques to look for an early, pre-symptom, diagnostic for diabetes. (Meet William!)

HAIGWOOD, NANCY L.<haigwood@u.washington.edu> is experimenting with DNA vaccines against SIV. She writes, "5 [out of] 6 macaques infected with pathogenic HIV-2 were protected from CD4 decline for more than two years after cessation of treatment, while 6/6 controls suffered decline. Time to disease and time to death were significantly different in control and treated groups." Elsewhere, she further explains her reasoning, if not her ethics, "The models presently under study are non-human primate lentiviruses, members of the retrovirus family that cause AIDS. In macaque monkeys, the major viruses are SIV, HIV-2, and recombinant viruses or chimeras of HIV-1 and SIV, called SHIV viruses. In SIV infection of macaques, the mean time to disease and death is one year."

HENDRICKSON, ANITA E. <anitah@u.washington.edu> is studying retinal development in pig-tailed macaques. Although it is unclear, it is possible that Hendrickson is given the eyes of monkeys killed by other researchers. If this is incorrect, the monkeys are killed solely to suppy Hendrickson's "needs." But in her fetal monkey brain labeling study their can be little doubt regarding her villainy. She writes, "We have obtained well-labeled monkey fetuses using intravenous injections of 3Hthymidine (3HT) into the pregnant female on a known day of gestation.... Currently three series are being collected ... with 4-5 fetuses in each series." (Meet Anita!)

HERR, JOHN C. <jch7k@virginia.edu> writes, "The mission of the Center for Recombinant Gamete Contraceptive Vaccine is to develop and test a safe, effective, reversible contraceptive vaccine. Emphasis is placed upon a vaccine for females ..." He will be using monkeys from WaRPRC. (Meet John!)

HULTGREN, SCOTT J. was giving macaques bladder infections. (1998)

HO, RODNEY <rodneyho@u.washington.edu> writes, "We have made significant progress toward achieving the first goal by using HIV-2 strain 287, which is highly pathogenic in the macaque, to infect the unique, chronically catheterized maternal-fetal macaque model. This HIV-2287-infected maternal-fetal model permits frequent and simultaneous sampling of maternal blood, fetal blood and the amniotic fluid in monitoring the immunological and virological response profiles of the dam and the fetus..."

highly pathogenic is the code for a disease that makes the monkeys deathy ill quite rapidly and always kills them.

chronically catheterized is the code for surgically implanting tubes into various areas, cavities, organs and vessels of the body.

maternal-fetal macaque model is the code for pregnant mothers and their babies having these chronic catheters sewn into them so that fluids and measurements could be taken while they died from the highly pahtogenic virus. (Meet Rodney!)

HU, SHIU-LOK <hus@u.washington.edu> is one of scores of researchers around the country sucking up AIDS research dollars. The perennial claim that studying a different disease (SIV) in a different species (any monkey) is wearing thin. The new tact to attract research bucks is the claim that combining two different diseases, SIV and HIV, into a new-to-the-world disease, SHIV, known nowhere else other than primate vivisection laboratories, will shed light on HIV in humans. As silly as this sounds, primate vivisection supporters in the government continue to throw millions of dollars at this scheme.