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- A lay examination of the experiments taking place, the claims, the c=
osts
to taxpayers, patients, and the monkeys
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- Research Statement:
- Modulation of neuroendocrine function by social status in female
primates; proximate mechanisms regulating female reproductive succes=
s;
ovarian
dysfunction in prenatally androgenized and obese female rhesus
monkeys.
- http://www.erp.wisc.ed=
u/faculty/abbott.html
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- Dr. David Abbott, Professor
- Department: Obstetrics & Gynecology; Wisconsin-National Primate
Center
- Mailing Address: 203 Primate Center, 1220 Capitol Court, Madison, WI
53715
- Telephone: (608) 263-3583 FAX: (608) 263-4031
- E-mail: abbott@primate.wisc.edu
- Background:
- Institution Degree Year Area of Study
- University of Edinburgh, Scotland B.Sc. 1975 Biological Sciences<=
/li>
- University of Edinburgh, Scotland Ph.D. 1979 Zoology
- University of WI-Madison Postdoc 1981 Repro. Physiology
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Professional
Experience:
1981-1984
Research Associate, Department of Anatomy, University of Cambridge,
England.
1984-1990
Research Fellow and Unit Head, Institute of Zoology, MRC/AFRC Comparati=
ve
Physiology Research Group, Zoological Society of London, England.
1990-present:
University of Wisconsin - Madison, Wisconsin, USA.
1990-1999
Chair, Physiological Ethology Research Group, Wisconsin Regional Primate
Research Center
1991-present
Joint Chief, Assay Services, Wisconsin Regional Primate Research
Center
1990-1992
Visiting Associate Professor, Department of Obstetrics and Gynecology a=
nd
Wisconsin Regional Primate Research Center
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- Hearn JP, Abbott DH, Chambers PC, Hodges JK, Lunn SF. Use of the com=
mon
marmoset, Callithrix jacchus, in reproductive research. Primates Med=
. 1978;10:40-9.
- Abbott DH, Hearn JP. The effects of neonatal exposure to testosteron=
e on
the development of behaviour in female marmoset monkeys. Ciba Found
Symp. 1978 Mar 14-16;(62):299-327.
- French JA, Abbott DH, Scheffler G, Robinson JA, Goy RW. Cyclic excre=
tion
of urinary oestrogens in female tamarins (Saguinus oedipus). J Reprod
Fertil. 1983 May;68(1):177-84.
- Abbott DH, Holman SD, Berman M, Neff DA, Goy RW. Effects of opiate
antagonists on hormones and behavior of male and female rhesus monke=
ys. Arch
Sex Behav. 1984 Feb;13(1):1-25.
- Abbott DH, Batty KA, Dubey AK, Herbert J, Shiers HM. The passage of 5
alpha-dihydrotestosterone from serum into cerebrospinal fluid and LH
negative feedback in castrated rhesus monkeys. J Endocrinol. 1985
Mar;104(3):325-30.
- Ruiz de Elvira MC, Abb=
ott
DH. A backpack system for long-term osmotic minipump infusions into
unrestrained marmoset monkeys. Lab Anim. 1986 Oct;20(4):329-34.
- Pryce CR, Abbott DH, Hodges JK, Martin RD. Maternal behavior is rela=
ted
to prepartum urinary estradiol levels in red-bellied tamarin monkeys=
. Physiol
Behav. 1988;44(6):717-26.
- Abbott DH, Hodges JK, George LM. Social status controls LH secretion=
and
ovulation in female marmoset monkeys (Callithrix jacchus). J Endocri=
nol.
1988 Jun;117(3):329-39.
- Faulkes CG, Abbott DH, Jarvis JU, Sherriff FE. LH responses of female
naked mole-rats, Heterocephalus glaber, to single and multiple doses=
of
exogenous GnRH. J Reprod Fertil. 1990 May;89(1):317-23.
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- Faulkes CG, Abbott DH. Social control of reproduction in breeding and
non-breeding male naked mole-rats (Heterocephalus glaber). J Reprod
Fertil. 1991 Nov;93(2):427-35.
- Barrett J, Abbott DH, George LM. Sensory cues and the suppression of
reproduction in subordinate female marmoset monkeys, Callithrix jacc=
hus.
J Reprod Fertil. 1993 Jan;97(1):301-10.
- Clarke AS, Wittwer DJ, Abbott DH, Schneider ML. Long-term effects of
prenatal stress on HPA axis activity in juvenile rhesus monkeys. Dev
Psychobiol. 1994 Jul;27(5):257-69.
- Margulis SW, Saltzman W, Abbott DH. Behavioral and hormonal changes =
in
female naked mole-rats (Heterocephalus glaber) following removal of =
the
breeding female from a colony. Horm Behav. 1995 Jun;29(2):227-47.
- Ziegler TE, Scheffler =
G,
Wittwer DJ, Schultz-Darken N, Snowdon CT, Abbott DH. Metabolism of
reproductive steroids during the ovarian cycle in two species of
callitrichids, Saguinus oedipus and Callithrix jacchus, and estimati=
on
of the ovulatory period from fecal steroids. Biol Reprod. 1996
Jan;54(1):91-9.
- Dumesic DA, Abbott DH,
Eisner JR, Goy RW. Prenatal exposure of female rhesus monkeys to
testosterone propionate increases serum luteinizing hormone levels in
adulthood. Fertil Steril. 1997 Jan;67(1):155-63.
- Eisner JR, Dumesic DA, Kemnitz JW, Abbott DH. Timing of prenatal
androgen excess determines differential impairment in insulin secret=
ion
and action in adult female rhesus monkeys. J Clin Endocrinol Metab. =
2000
Mar;85(3):1206-10.
- Smith TE, Tomlinson AJ, Mlotkiewicz JA, Abbott DH. Female marmoset
monkeys (Callithrix jacchus) can be identified from the chemical
composition of their scent marks. Chem Senses. 2001 Jun;26(5):449-58=
.
- Dumesic DA, Schramm RD, Peterson E, Paprocki AM, Zhou R, Abbott DH. =
Impaired
developmental competence of oocytes in adult prenatally androgenized
female rhesus monkeys undergoing gonadotropin stimulation for in vit=
ro
fertilization. J Clin Endocrinol Metab. 2002 Mar;87(3):1111-9.
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- Eisner JR, Dumesic DA, Kemnitz JW, Colman RJ, Abbott DH. Increased
adiposity in female rhesus monkeys exposed to androgen excess during
early gestation. Obes Res. 2003 Feb;11(2):279-86.
- Dumesic DA, Schramm RD, Bird IM, Peterson E, Paprocki AM, Zhou R, Ab=
bott
DH. Reduced intrafollicular androstenedione and estradiol levels in
early-treated prenatally androgenized female rhesus monkeys receiving
follicle-stimulating hormone therapy for in vitro fertilization. Biol
Reprod. 2003 Oct;69(4):1213-9. Epub 2003 Jun 11.
- Abbott DH, Barnett DK, Colman RJ, Yamamoto ME, Schultz-Darken NJ. As=
pects
of common marmoset basic biology and life history important for
biomedical research. Comp Med. 2003 Aug;53(4):339-50. Review.
- Schultz-Darken NJ, Pape RM, Tannenbaum PL, Saltzman W, Abbott DH. No=
vel
restraint system for neuroendocrine studies of socially living common
marmoset monkeys. Lab Anim. 2004 Oct;38(4):393-405.
- Bruns CM, Baum ST, Colman RJ, Eisner JR, Kemnitz JW, Weindruch R, Ab=
bott
DH. Insulin resistance and impaired insulin secretion in prenatally
androgenized male rhesus monkeys. J Clin Endocrinol Metab. 2004
Dec;89(12):6218-23.
- Saltzman W, Abbott DH. Diminished maternal responsiveness during
pregnancy in multiparous female common marmosets. Horm Behav. 2005
Feb;47(2):151-63. Epub 2004 Dec 15.
- Abbott DH, Barnett DK, Bruns CM, Dumesic DA. Androgen excess fetal
programming of female reproduction: a developmental aetiology for
polycystic ovary syndrome? Hum Reprod Update. 2005 Jul-Aug;11(4):357=
-74.
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- 5/1/02-4/30/07 M. Cadwallader (PI) NIH P51-RR00167. [2004: $8,897,24=
7]
Sub project Assay Service Unit
- 5/1/02-4/30/07 M. Cadwallader (PI) NIH P51-RR00167. Directors Office
Office: Sub project Marmoset Development Leadership
- 9/1/02-8/31/07 A. Dunaif (PI) David Abbott (PI UW on UW sub-contract)
NIH P50-HD44405. Genes, androgens and intrauterine environment in PC=
OS
- 9/1/03-8/31/07 D.A. Dumesic (PI) David Abbott (PI on UW sub-contract)
NIH U01-HD044650-01. Paracrine dysregulation of oocyte competence in
PCOS
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- 2002: 5R01RR013635-04<=
span
style=3D'mso-spacerun:yes'> ANDROGENIZED FEMALE A=
S A
MODEL FOR P0LYCYSTIC OVARIAN SY $324,419
- 2001: 5R01RR013635-03<=
span
style=3D'mso-spacerun:yes'> ANDROGENIZED FEMALE A=
S A
MODEL FOR P0LYCYSTIC OVARIAN SY $326,977
- 2000: 5R01RR013635-02<=
span
style=3D'mso-spacerun:yes'> ANDROGENIZED FE=
MALE
AS A MODEL FOR P0LYCYSTIC OVARIAN SY $316,992
- 1999: 1R01RR013635-01A=
1 ANDROGENIZED FEMALE A=
S A
MODEL FOR P0LYCYSTIC OVARIAN SY $327,152
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